Adv Prostaglandin Thromboxane Leukot Res., (1987) 17B:946-8

Prostaglandin D2 Induces Sleep When Infused into the Cerebral Ventricle of Conscious Monkeys

*O. Hayaishi, *R. Ueno, *H. Onoe, *H. Osama, **I. Fujita, H. **Nishino, and **Y. Oomura
*Hayaishi Bioinformation Transfer Project, Research Development Corporation of Japan. : and **National Institute for Physiological Science.

In a previous series of experiments from our laboratory, we showed the following: (a) One of the major prostaglandins (PGs) in the CNS of the rat is PGD2; (b) PGD2 receptors are highly concentrated in the preoptic area, which is considered to be a center of sleep regulation; (c) microinjection into the preoptic area or intracerebroventricular infusion of as little as 1 fmol/sec PGD2 into rats induces sleep, which is indistinguishable from natural sleep on the basis of electroencephalogram (EEG), electromyogram (EMG), and behavior; (d) the effect is dose-dependent and specific for PGD2. Other PGs such as E2 and F2a are much less effective or totally inactive; (e) inhibitors of PG synthesis decrease the amount of diurnal sleep of rats.
Based on these lines of evidence, we proposed that PGD2 is the natural sleep modulator in the rat (1). In this chapter we report our recent results, using rhesus monkeys (Macaca mulatta), that PGD2 is also a sleep-inducing agent in primates.