第10回日本神経科学学術集会(大阪)1986.12.6

 「視床下部がallogroomingの制御に関与している」 

藤田一郎、小山純正、吉松博信、粟生修司、西野仁雄、大村裕
生理学研究所高次液性調節

サルのgrooming(毛づくろい)には、自身に対して行うselfgroomngと他に対して行うallogroomingがある。われわれはアカゲザルを用いてこれらの行動発現に対する視床下部の関与を調べた。単一ニューロン活動を記録したところ、自発的に起きたallogrooming中に活動の促進または抑制を示すニューロンが視床下部に存在した。視床下部外側野および外側視束前野に与えた局所電気刺激は、allogroomingを誘発したがselfgroomingは誘発しなかった。電気刺激有効部位へ微量注入したグルタミン酸ナトリウムは、allogroomingを促進した。以上の結果は、視床下部の主に外側部のニューロンがallogroomingの制御に関与していることを示している。



The lateral and dorsomedial hypothalamus facilitates allogrooming in the monkey.

Neurosci. Res. Suppl. 4: s88.

Fujita, I.1, Koyama, Y.1*, YOSHIMATSU, H.2, Aou, S., Nishino, H.1,2 and Oomura, Y.1,3
1 Natl. Inst. Physiol. Sci., Okazaki 444;
2 Toyama Med. Pharmaceut. Univ., Toyama 930-O1;
3 Dept. Physiol., Fac. Med., Kyushu Univ., Fukuoka 812 (Japan)

Allogrooming (AG) is the most common form of social behavior performed by non-human primates. It establishes and maintains a variety of relationships, reduces tension and promotes alliances between individuals. However, the neural substrate implicated in AG is largely unknown compared to other social behaviors including vocal communication, aggression and sexual behavior. We report here that the hypothalamus contains a neural system which facilitates AG. Two male and one ovariectomized, estrogen-treated female rhesus monkeys were acquired and used in accordance with the NIH Guide (1985). Allogrooming was reproducibly evoked by electrical stimuli (0.5 ms, 50 Hz, 10-300 μA, 2.5 sec) to the lateral preoptic area (LPOA), lateral hypothalamic area (LHA) and dorsomedial hypothalamic nucleus (DMH). When we removed the partner monkey, or replaced it with a non-living object or an experimenter, stimulation did not elicit any behavior. This exclude the possibility that electrical stimuli evoke simple arm extension which accidentally results in AG. Selfgrooming (SG) was not evoked from any sites. Sodium-glutamate solution of either 10, 33 or 100 mM injected at a rate of 0.5 μl/min for 6 min markedly facilitated AG without affecting SG, when infused into the loci where electrical shocks evoked AG in the LHA or DMH. No behavioral effect was observed after injection of saline into these sites. Extracellular unit recording in behaving monkeys showed that some neurons in the LPOA, LHA and DMH changed their activity during spontaneous AG. In some of the neurons examined, the activity- change seemed specific to AG, i.e., they changed their activity during AG, but not during sexual behavior neither in response to passive arm movement forced by an experimenter or tactile stimuli to the hand. The present study provide the first unequivocal evidence for the neural substrate involved in AG that the lateral and dorsomedial hypothalamus facilitates this behavior. Supported by Itoh Science Foundation and the Ministry of Education, Science and Culture.