第10回神経科学学術集会(大阪)1986.12.5-6

「プロスタグランジンD2の睡眠誘発作用」
上野隆司、尾上浩隆、早石修、藤田一郎、西野仁雄、大村裕  



Sleep inducing effects of PGD2.

Neurosci. Res. Suppl. 4: s173.

R. Ueno*, H. Onoe*, O. Hayaishi*, I. Fujita+, H. Nishino+, and Y. Oomura+

*Hayaishi Bioinformation Transfer Project, Research Development Corporation of Japan
+ National Institute for Physiological Science, Okazaki 444, Japan

In a series of previous experiments from our laboratory, micro-injection of prostaglandin (PG) D2, into the preoptic area of conscious rats and intra-cerebroventricular administration of as little as one fmol/sec of PGD2 to rats were shown to induce physiological sleep. Further, serevral PG synthetase inhibitors decreased the amount of diurnal sleep of rats indicating that endogeneous PGD2 in brain may regulate daily sleep patterns of monkeys (Macaca Mulatta). Intraventricular infusion of PGD2 at 15-2250 pmol/min dose- dependently increased the amount of sleep in four monkeys, although sensitivities to PGD2 were slightly different among individual monkeys. The sleep caused by PGD was physiological i.e. deep slow wave sleep and REM sleep appeared in physiological proportions. These demonstrate that PGD2 serves as a cerebral sleep regulating substance not only in rodents but also in primates.