第62回日本生理学会(久留米)1985.3.
J. Physiol. Soc. Japan 47: 436.


サル青斑核の摂食課題時におけるニューロン活動
藤田一郎、粟生修司、山本智矢、中野保彦、西野仁雄、大村裕

青斑核(LC)の摂食行動における働きを検討する目的で、無麻酔ニホンザルのLCおよびその近傍より、オペラント摂食行動時の単一ニューロン活動を記録した。その結果、手がかり刺激である光および音の刺激さらに食物報酬の呈示により、活動の上昇を示すニューロンが観察された。また、レバー押し中に活動の変化を示すものもあった。このように、LCニューロンは摂食課題時に複雑な活動変化を示した。



Neuronal activity in the locus coeruleus and its adjacent areas during feeding behavior in the monkey.

Fujita, I., Aou, S., Yamamoto,T., Nakano, Y., Nishino, H. and Oomura, Y.
Dept. Biol. Control System, Nat. Inst. Physiol. Sci., Okazaki 444

Extracellular single neuron activity was recorded during operant feeding behavior in and near the locus coeruleus of the monkey. Neurons analysed may include those in the locus coeruleus as well as in the medial parabrachial nucleus and the lateral part of the pontine central gray. The paradigm was a high fixed ratio (FR 20) bar press task: 1) a cue light signaled a monkey to start bar presses, 2) on the 20th bar press, a cue buzzer signaled delivery of food, and 3) the monkey took and ate food. Of 21 neurons analysed, 16(76%) increased firing rate responding to a cue light and delivery of food. Eleven cells (52%) increased firing rate after a cue buzzer. During the bar press period, 6 cells (29%) decreased, but no cells increased, firing rate. After the monkey put food into the mouth, firing rate was increased in 6 cells (29%) and decreased in 2 cells (9%). Thus, many neurons in this region responded to visual or auditory stimuli, but we could not find any cells showing firing increase during food acquisition (bar press period).

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