第8回神経科学学術集会(大阪)1984.11.

「自発的発声に始まる摂食課題時のサル前頭眼窩野および視床下部外側野ニューロン活動

山本智矢、大村裕、西野仁雄、粟生修司、中野保彦、小山純正、藤田一郎

サルの欲求(発声行動)によって始まるレバー押し摂食課題時の前頭眼窩野(OBF)ニューロン活動を記録した。発声行動に先行して活動が変化するニューロンが約25%存在した。視床下部外側野(LHA)にも同様なニューロンが約20%存在した。しかし両者の活動パターンは異なっていた。これらの結果からOBFとLHAの摂食行動の開始に果たす役割について考察する。



Yamamoto, T., Oomura, Y., Nishino, H., Aou, S., Nakano, Y., Koyama, Y. and Fujita, I. (1984)
Vocalization-initiated feeding task and neuronal activity in the monkey orbitofrontal cortex and lateral hypothalamic area.
Neurosci. Res. Suppl. 1: s6.


To elucidate the motivational mechanism involved in the initiation of feeding behavior, single neuron activity was recorded in the monkey lateral hypothalamic area (LHA) and the orbitofrontal cortex(OBF), both of them have been reported to play an important role on control of feeding behavior, during a vocalization-initiated feeding task. The present task paradigm was as follows: the monkey (Maraca fuscata), seated in a primate chair, was requested to vocalize an SE subtype of "coo" sound to turn a cue light on, which meant a "GO" sign of the task. After that, the monkey could press a bar 30 times, and food was presented as a reward after a cue tone stimuli. The neuronal activity during conventional bar press feeding task signaled by a cue light on, was studied as a control task. 14 LHA neurons (36%) showed approximately 2 sec preceding activity change to vocalization. Most of them (12) showed an increase irk activity and 2, a decrease. 14 OBF neurons (24%) showed preceding activity change; 8 showed an increase and 6 a decrease. The activity pattern of OBF neurons which showed preceding activity change was different from those of LHA neurons. All of these neurons also showed preceding activity change when the task was initiated by a requesting bar press instead of vocalization, meaning that the preceding change was not related to vocalization itself. These results suggest that both the OBF and LHA are related to the motivational mechanism to initiate the task, but in a different manner.


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