Yamamoto, T., Oomura, Y., Nishino, H., Aou, S., Nakano, Y., Koyama, Y. and Fujita, I. (1984)
Vocalization-initiated feeding task and neuronal activity in the monkey orbitofrontal cortex and lateral hypothalamic area.
Neurosci. Res. Suppl. 1: s6.
To elucidate the motivational mechanism involved in the initiation of feeding behavior, single neuron activity was recorded in the monkey lateral hypothalamic area (LHA) and the orbitofrontal cortex(OBF), both of them have been reported to play an important role on control of feeding behavior, during a vocalization-initiated feeding task. The present task paradigm was as follows: the monkey (Maraca fuscata), seated in a primate chair, was requested to vocalize an SE subtype of "coo" sound to turn a cue light on, which meant a "GO" sign of the task. After that, the monkey could press a bar 30 times, and food was presented as a reward after a cue tone stimuli. The neuronal activity during conventional bar press feeding task signaled by a cue light on, was studied as a control task. 14 LHA neurons (36%) showed approximately 2 sec preceding activity change to vocalization. Most of them (12) showed an increase irk activity and 2, a decrease. 14 OBF neurons (24%) showed preceding activity change; 8 showed an increase and 6 a decrease. The activity pattern of OBF neurons which showed preceding activity change was different from those of LHA neurons. All of these neurons also showed preceding activity change when the task was initiated by a requesting bar press instead of vocalization, meaning that the preceding change was not related to vocalization itself. These results suggest that both the OBF and LHA are related to the motivational mechanism to initiate the task, but in a different manner.