第32回日本神経科学大会

会期:2009.9.16-18
会場: 名古屋国際会議場

側頭葉視覚連合野の樹状突起スパイン形態は一次視覚野より多様である
Dendritic spine size varies more in area TE than in area V1
演題番号 : P2-b11 ポスター発表 発表日:2009.9.17

小賀 智文(Tomofumi Oga):1 岡本 嗣久(Tsuguhisa Okamoto):1 Guy N. Elston:2,3 藤田 一郎(Ichiro Fujita):1,3 

1:大阪大院・生命機能(Grad Sch Frontier Biosciences, Osaka Univ, Japan) 2:Centre for Cognitive Neuroscience, Queensland, Australia 3:CREST, 科学技術振興機構(CREST, JST, Japan)


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Dendritic spines are the major postsynaptic sites of excitatory synapses in pyramidal cells. Morphology of dendritic spines influences their physiological properties. The size of spine head correlates with synaptic efficacy. Theretical analysis has suggested that information storage capacity of a neuronal network increases with variation of synaptic weights. Here we investigated morphology of dendritic spines of layer III pyramidal cells in the primary visual cortex (V1) and visual association cortex (TE) in monkeys by intracellular dye injection technique. We found that dendritic spines were more diverse in their head size in TE than in V1 (p < 0.001; bootstrap test for standard deviation of spine head diameter). The mean spine head diameter did not differ between the two areas (p > 0.05; Mann-Whitney's U-test). The greater variety (present results) and number (Elston et al., 1999) of dendritic spines in TE as compared to V1 suggests that TE have larger information storage capacity than V1.