第31回日本神経科学大会

日程:2008年7月9日(水)から11日(木)
場所:東京都千代田区丸の内3丁目 東京国際フォーラム

発表日: 2008年7月9日
発表形式: ポスター
抄録P1-j05

Hierarchical development in macaque visual cortex

小賀智文、Guy N. Elston、藤田一郎

抄録本文:
Spinogenesis and synaptic pruning during development via Hebbian-type reinforcement are widely believed to subserve connectional specificity. The magnitude and timing of spinogenesis and pruning in the cerebral cortex remain controversial. Here we studied pyramidal cells (n = 369) in macaque monkeys (Macaca fascicularis) to determine their synaptogenic profiles during development (2 days to 4.5 years old). Synaptogenic profiles of pyramidal cells in the primary visual area (V1) were compared with those in visual association area TE. Neurons were injected individually with Lucifer yellow in fixed cortical slices and processed for a DAB product. We found exuberant spinogenesis and pruning in the dendritic trees of pyramidal cells in both V1 and TE. However the timing and magnitude
differed considerably between groups. These data support the theory of a hierarchical developmental timecourse of synaptogenesis in the cerebral cortex.