第30回日本神経科学大会(横浜)
平成19年9月10日〜12日

発表日時:9月11日
抄録番号:P2-e-34

Developmental changes in electrophysiological properties of layer III pyramidal neurons in macaque visual cortices.
マカクザル視覚皮質における第III層錐体細胞の電気生理学的性質の発達による変化

Maruyama, A., Ishikawa, A., Hosoyama, D., Yoshimura, Y., Tamura, H., Sato, H., Fujita, I.
丸山敦子、石川理子、細山大輔、吉村由美子、田村弘、佐藤宏道、藤田一郎

We studied developmental changes of intrinsic membrane properties of layer III pyramidal neurons in the striate (V1) and inferior temporal (TE) cortices of macaque monkeys. Whole-cell patch-clamp techniques were applied to slices prepared from animals of different ages (10 days, 7-8 months, adult). The membrane time constant decreased with age in both V1 and TE. In V1, the value at 7-8 months was already close to that in adults, while in TE it gradually decreased up to adulthood. Inward rectification in response to hyperpolarization became stronger with age, and this change was more evident in V1 than in TE. In both areas, the maximal rate of firing in response to depolarizing current injection increased with age, and the duration of individual action potentials shortened. The results demonstrate that electrophysiological properties of cortical neurons in monkeys become matured over a prolonged period after birth, which may contribute to refinement of visual responsiveness during development.