Program Number O1P-C16
"Comparison of electrophysiological properties of layer III pyramidal neurons between cortical areas V1 and TE of the macaque"
Ayako Ishikawa1, Atsuko Maruyama2, Daisuke Hosoyama1, Yumiko Yoshimura2, 3, Hiroshi Tamura1, 2, Hiromichi Sato4, Ichiro Fujita1,2
1 Osaka Univ., Grad. Sch. Frontier Biosci., Japan
2 CREST, JST, Japan
3 Nagoya Univ., Japan
4 Osaka Univ., Grad. Sch. Med., Japan
Electrophysiological properties of layer III pyramidal neurons were compared between areas V1 and TE, the two ends of the ventral visual cortical pathway in macaque monkeys. We applied whole-cell patch-clamp techniques to brain slices taken from adult animals. Neurons in the two areas markedly differed in several electrophysiological properties; 1) the membrane time constant was smaller and the input resistance was higher in V1 than in TE, 2) the rate of spike firing evoked by a long-duration (500 ms) depolarizing current pulse was more rapidly and strongly attenuated in V1 than in TE, and 3) the rise time of miniature excitatory postsynaptic currents in V1 was shorter than that in TE. The results suggest that V1 neurons are suited for processing information with higher temporal resolution, while the properties of TE neurons have an advantage in integrating information over a longer time range.