第29回日本神経科学大会(京都)
平成18年7月19日〜21日
Program Number: PS2A-E066 Presentation Time: Thursday, July. 20, 11:00 - 12:00

Dendritic morphology of layer III pyramidal cells differs among cortical areas in infant monkeys

Koji Ikezoe1, Guy N. Elston2,3, Tomofumi Oga1, Hiroshi Tamura1,3, Ichiro Fujita1,3

1Osaka Univ., Japan, 2Univ. Queensland, Australia, 3CREST, JST, Japan

Layer III pyramidal cells in adult monkeys exhibit systematic differences in their dendritic morphology among cortical areas. Basal dendrites of cells in visual association cortex such as inferior temporal area TE spread more extensively and are more branched than those in the primary visual cortex (V1). Pyramidal cells in prefrontal cortex, such as area 12, have even more dendritic branches than those in area TE. Here, we investigated whether a similar regional difference in the dendritic morphology was present in infant monkeys. We stained individual layer III pyramidal cells in V1 (n=52), area TE (n=46), and area 12 (n=43) of a 3-week old monkey (Macaca fascicularis) using intracellular dye-injection techniques in lightly fixed tissues. The number of branches and the tangential extent of dendrites was greatest in area 12, followed by area TE, and V1. Thus, considerable heterogeneity in pyramidal cell structure already exists 3-weeks after birth.

Keywords: VISUAL SYSTEM, DENDRITE, MORPHOLOGY, DEVELOPMENT

Reserch Funds: This research was supported by CREST, JST, Japan and NHMRC, Aulstralia