第27回日本神経科学大会(大阪)

P2-086 Identification of genes differentially expressed between V 1 and area TE of the macaque monkey

Yosuke Matsuoka1, Shun Hamada1, Hiroshi Tamura1, Hiroyuki Yoneshima1, Takeshi Yagi1, Ichiro Fujita1

1.KOKORO Biology Group and Cognitive Neuroscience Group, Graduate School of Frontier Biosciences, Osaka University, Suita and Toyonaka, Japan

The cerebral cortex of the macaque monkey contains a number of functionally and structurally different visual areas. Little is known, however, about how these areas differ at the molecular level. We applied the method of PCR-based cDNA subtraction and northern blotting to identify genes differentially expressed between two different areas. Here we focused on the primary visual cortex (V1) and area TE of the inferior temporal cortex, the first and final stages in the ventral cortical pathway, which is crucially involved in visual recognition of objects. Although we could not find genes more abundantly expressed in V1, 5 genes were found preferentially expressed in area TE. Interestingly, all the 5 genes encode proteins that are potentially involved in the dynamism of synapses or dendrites. The results provide a new aspect of the molecular characterization of V 1 and TE.

2004 Elsevier Science Ireland Ltd. and the Japan Neuroscience Society. All rights reserved.